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doi:10.22028/D291-33329
Titel: | Striatal dopamine transporters and cognitive function in Parkinson's disease |
VerfasserIn: | Stögbauer, Jakob Rosar, Florian Dillmann, Ulrich Faßbender, Klaus Ezziddin, Samer Spiegel, Jörg |
Sprache: | Englisch |
Titel: | Acta Neurologica Scandinavica |
Bandnummer: | 142 |
Heft: | 4 |
Seiten: | 385–391 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2020 |
Freie Schlagwörter: | cognitive deficits dopamine transporters FP‐CIT SPECT Parkinson’s disease |
DDC-Sachgruppe: | 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Background Idiopathic Parkinson’s disease (PD) is characterized by clinical motor symptoms including hypokinesia, rigidity and tremor. In addition to the movement disorder, cognitive deficits are commonly described. In the present study, we applied FP‐CIT SPECT to investigate the impact of nigrostriatal dopaminergic degeneration on cognitive function in PD patients. Methods Fifty‐four PD patients underwent [123I]FP‐CIT SPECT and CERAD (Consortium to Establish a Registry for Alzheimer’s Disease) testing. FP‐CIT SPECT visualized the density of presynaptic dopamine transporters in both striata, each subdivided into a limbic, executive and sensorimotor subregion according to the atlas of Tziortzi et al (Cereb Cortex 24, 2014, 1165). CERAD testing quantified cognitive function. Results In the CERAD testing, PD patients exhibited deficits in the domains of semantic memory, attention, visuospatial function, non‐verbal memory and executive function. After correction for multiple testing, the performance of the subtests Figure Recall and Trail‐Making Test A correlated significantly with FP‐CIT uptake into the ipsilateral executive subregion. The performance of the subtest Figure Saving correlated significantly with FP‐CIT uptake into the contralateral executive subregion. Conclusions The significant correlation between cognitive function and density of nigrostriatal dopamine transporters, as assessed by FP‐CIT SPECT, indicate that striatal dopaminergic pathways—primarily the executive striatal subregion—are relevant to cognitive processing in PD. |
DOI der Erstveröffentlichung: | 10.1111/ane.13320 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-333298 hdl:20.500.11880/30677 http://dx.doi.org/10.22028/D291-33329 |
ISSN: | 1600-0404 0001-6314 |
Datum des Eintrags: | 18-Feb-2021 |
Fakultät: | M - Medizinische Fakultät |
Fachrichtung: | M - Neurologie und Psychiatrie M - Radiologie |
Professur: | M - Prof. Dr. Klaus Faßbender M - Prof. Dr. Samer Ezziddin |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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ane.13320.pdf | 520,78 kB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons