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Titel: Plasma levels of osteopontin from birth to adulthood
VerfasserIn: Nourkami-Tutdibi, Nasenien UdsID
Graf, Norbert UdsID
Beier, Rita
Zemlin, Michael UdsID
Tutdibi, Erol UdsID
Sprache: Englisch
In:
Titel: Pediatric Blood & Cancer
Bandnummer: 67
Heft: 7
Verlag/Plattform: Wiley
Erscheinungsjahr: 2020
Freie Schlagwörter: biomarker
blood plasma
cord blood
oncogene
osteopontin
pediatric reference values
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Aim Osteopontin (OPN) has been investigated as a biomarker for cancer and nonmalignant diseases during the last decades. Data about OPN as a potential biomarker in childhood diseases are still sparse, and reference values are not available in children. We aimed to establish reference values for children from birth to young adulthood and evaluate whether there are age‐, gender‐, and weight‐specific differences. Method Umbilical cord blood and blood plasma samples of 117 children were collected in the Children's Hospital of Saarland University in Homburg/Saar. OPN levels were measured by ELISA, and statistical analysis was performed using SPSS software. Results Neonates, infants, toddlers, young children, adolescents, and adults were divided into the following six age groups: newborns (birth), infancy and toddlers (0‐24 months), early childhood (3‐6 years), middle childhood (7‐11 years), adolescence (12‐18 years), and adults (> 18 years). Highest blood OPN levels were found in the group of 0‐1 years of age. OPN blood levels declined significantly with age (Spearman r = −0.874; P < 0.001). Conclusion Our work is the first prospective and systematic study analyzing OPN cord blood and blood plasma levels in children of all ages. It is the first study yielding reference values for different age groups from birth to young adulthood. Our data give insight on how OPN in umbilical cord blood and OPN in blood plasma are physiologically influenced during childhood development and growth with high OPN levels after birth and a constant age‐related decline until the age of 14, when OPN levels reach similar values to those measured in adults.
DOI der Erstveröffentlichung: 10.1002/pbc.28272
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-332578
hdl:20.500.11880/30607
http://dx.doi.org/10.22028/D291-33257
ISSN: 1545-5017
1545-5009
Datum des Eintrags: 10-Feb-2021
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fpbc.28272&file=pbc28272-sup-0001-TableS1.docx
https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fpbc.28272&file=pbc28272-sup-0002-TableS2.docx
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Pädiatrie
Professur: M - Prof. Dr. Norbert Graf
M - Prof. Dr. Michael Zemlin
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes



Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons