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Titel: NIR-Emitting Gold Nanoclusters-Modified Gelatin Nanoparticles as a Bioimaging Agent in Tissue
VerfasserIn: El-Sayed, Nesma
Trouillet, Vanessa
Clasen, Anne
Jung, Gregor
Hollemeyer, Klaus
Schneider, Marc
Sprache: Englisch
Titel: Advanced Healthcare Materials
Bandnummer: 8
Heft: 24
Verlag/Plattform: Wiley
Erscheinungsjahr: 2019
Freie Schlagwörter: drug delivery
fluorescent enhancement
nanotechnology
protein-stabilized gold nanoclusters
theranostics
DDC-Sachgruppe: 500 Naturwissenschaften
600 Technik
610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Gold nanocluster (AuNC) synthesis using a well-distinguished polymer for nanoparticle-mediated drug delivery paves the way for developing efficient theranostics based on pharmaceutically accepted materials. Gelatin-stabilized AuNCs are synthesized and modified by glutathione for tuning the emission spectra. Addition of silver ions enhances the fluorescence, reaching also high quantum yield (26.7%). A simplified model can be proposed describing the nanoclusters' properties-structure relationship based on X-ray photoelectron spectroscopy data and synthesis sequence. Furthermore, these modifications improve fluorescence stability toward pH changes and enzymatic degradation, offering different AuNCs for various applications. The impact of nanocluster formation on gelatin structure integrity is investigated by Fourier transform infrared spectrometry and matrix-assisted laser desorption/ionization time of flight mass spectroscopy, being important to further formulate gelatin nanoparticles (GNPs). The 218 nm-sized NPs show no cytotoxicity up to 600 µg mL-1 and are imaged in skin, as a challenging autofluorescent tissue, by confocal microscopy, when transcutaneously delivered using dissolving microneedles. Linear unmixing allows simultaneous imaging of AuNCs-GNPs and skin with accurate signal separation. This underlines the great potential for bioimaging of this system to better understand nanomaterials' behavior in tissue. Additionally, it is drug delivery system also potentially serving as a theranostic system.
DOI der Erstveröffentlichung: 10.1002/adhm.201900993
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-332352
hdl:20.500.11880/30583
http://dx.doi.org/10.22028/D291-33235
ISSN: 2192-2659
2192-2640
Datum des Eintrags: 8-Feb-2021
Bezeichnung des in Beziehung stehenden Objekts: Supporting Information
In Beziehung stehendes Objekt: https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.201900993&file=adhm201900993-sup-0001-SuppMat.pdf
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Chemie
NT - Pharmazie
Professur: NT - Prof. Dr. Gregor Jung
NT - Prof. Dr. Marc Schneider
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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