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doi:10.22028/D291-33235
Titel: | NIR-Emitting Gold Nanoclusters-Modified Gelatin Nanoparticles as a Bioimaging Agent in Tissue |
VerfasserIn: | El-Sayed, Nesma Trouillet, Vanessa Clasen, Anne Jung, Gregor Hollemeyer, Klaus Schneider, Marc |
Sprache: | Englisch |
Titel: | Advanced Healthcare Materials |
Bandnummer: | 8 |
Heft: | 24 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2019 |
Freie Schlagwörter: | drug delivery fluorescent enhancement nanotechnology protein-stabilized gold nanoclusters theranostics |
DDC-Sachgruppe: | 500 Naturwissenschaften 600 Technik 610 Medizin, Gesundheit |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Gold nanocluster (AuNC) synthesis using a well-distinguished polymer for nanoparticle-mediated drug delivery paves the way for developing efficient theranostics based on pharmaceutically accepted materials. Gelatin-stabilized AuNCs are synthesized and modified by glutathione for tuning the emission spectra. Addition of silver ions enhances the fluorescence, reaching also high quantum yield (26.7%). A simplified model can be proposed describing the nanoclusters' properties-structure relationship based on X-ray photoelectron spectroscopy data and synthesis sequence. Furthermore, these modifications improve fluorescence stability toward pH changes and enzymatic degradation, offering different AuNCs for various applications. The impact of nanocluster formation on gelatin structure integrity is investigated by Fourier transform infrared spectrometry and matrix-assisted laser desorption/ionization time of flight mass spectroscopy, being important to further formulate gelatin nanoparticles (GNPs). The 218 nm-sized NPs show no cytotoxicity up to 600 µg mL-1 and are imaged in skin, as a challenging autofluorescent tissue, by confocal microscopy, when transcutaneously delivered using dissolving microneedles. Linear unmixing allows simultaneous imaging of AuNCs-GNPs and skin with accurate signal separation. This underlines the great potential for bioimaging of this system to better understand nanomaterials' behavior in tissue. Additionally, it is drug delivery system also potentially serving as a theranostic system. |
DOI der Erstveröffentlichung: | 10.1002/adhm.201900993 |
Link zu diesem Datensatz: | urn:nbn:de:bsz:291--ds-332352 hdl:20.500.11880/30583 http://dx.doi.org/10.22028/D291-33235 |
ISSN: | 2192-2659 2192-2640 |
Datum des Eintrags: | 8-Feb-2021 |
Bezeichnung des in Beziehung stehenden Objekts: | Supporting Information |
In Beziehung stehendes Objekt: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Fadhm.201900993&file=adhm201900993-sup-0001-SuppMat.pdf |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Chemie NT - Pharmazie |
Professur: | NT - Prof. Dr. Gregor Jung NT - Prof. Dr. Marc Schneider |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Dateien zu diesem Datensatz:
Datei | Beschreibung | Größe | Format | |
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adhm.201900993.pdf | 3,47 MB | Adobe PDF | Öffnen/Anzeigen |
Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons