Please use this identifier to cite or link to this item: doi:10.22028/D291-33211
Title: ER import of small human presecretory proteins: components and mechanisms
Author(s): Haßdenteufel, Sarah
Nguyen, Duy
Helms, Volkhard
Lang, Sven
Zimmermann, Richard
Language: English
Title: FEBS Letters
Volume: 593
Issue: 18
Pages: 2506–2524
Publisher/Platform: Wiley
Year of Publication: 2019
Free key words: endoplasmic reticulum
post-translational protein import
Sec61 complex
signal recognition particle
small presecretory proteins
DDC notations: 500 Science
600 Technology
610 Medicine and health
Publikation type: Journal Article
Abstract: Protein transport into the mammalian endoplasmic reticulum (ER) used to be seen as strictly cotranslational, that is temporarily and mechanistically coupled to protein synthesis. In the course of the last decades, however, several classes of precursors of soluble and membrane proteins were found to be post-translationally imported into the ER, without any involvement of the ribosome. The first such class to be identified were the small presecretory proteins; tail-anchored membrane proteins followed next. In both classes, the inherent address tag is released from the translating ribosome before the initiation of ER import, as part of the fully synthesized precursor. In small presecretory proteins, the information for ER targeting and -translocation via the polypeptide-conducting Sec61-channel is encoded by a classical N-terminal signal peptide, which is released from the ribsosome before targeting due to the small size of the full-length precursor. Here, we discuss the current state of research on targeting and translocation of small presecretory proteins into the mammalian ER. In closing, we present a unifying hypothesis for ER protein translocation in terms of an energy diagram for Sec61-channel gating.
DOI of the first publication: 10.1002/1873-3468.13542
Link to this record: urn:nbn:de:bsz:291--ds-332112
ISSN: 1873-3468
Date of registration: 5-Feb-2021
Description of the related object: Supporting Information
Related object:
Faculty: M - Medizinische Fakultät
NT - Naturwissenschaftlich- Technische Fakultät
Department: M - Medizinische Biochemie und Molekularbiologie
NT - Biowissenschaften
Professorship: M - Keiner Professur zugeordnet
NT - Prof. Dr. Volkhard Helms
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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