Please use this identifier to cite or link to this item: doi:10.22028/D291-33175
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Title: Persistence-Speed Coupling Enhances the Search Efficiency of Migrating Immune Cells
Author(s): Shaebani, M. Reza
Jose, Robin
Santen, Ludger
Stankevicins, Luiza
Lautenschläger, Franziska
Language: English
Title: Physical review letters
Volume: 125
Issue: 26
Publisher/Platform: APS
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Migration of immune cells within the human body allows them to fulfill their main function of detecting pathogens. We present experimental evidence showing the optimality of the search strategy of these cells, which is of crucial importance to achieve an efficient immune response. We find that the speed and directional persistence of migrating dendritic cells in our in vitro experiments are highly correlated, which enables them to reduce their search time. We introduce theoretically a new class of random search optimization problems by minimizing the mean first-passage time (MFPT) with respect to the strength of the coupling between influential parameters. We derive an analytical expression for the MFPT in a confined geometry and verify that the correlated motion enhances the search efficiency if the mean persistence length is sufficiently shorter than the confinement size. Our correlated search optimization approach provides an efficient searching recipe and predictive power in a broad range of correlated stochastic processes.
DOI of the first publication: 10.1103/PhysRevLett.125.268102
URL of the first publication: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.125.268102
Link to this record: hdl:20.500.11880/30506
http://dx.doi.org/10.22028/D291-33175
ISSN: 1079-7114
0031-9007
Date of registration: 1-Feb-2021
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Jun.-Prof. Dr. Franziska Lautenschläger
Collections:Die Universitätsbibliographie

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