Please use this identifier to cite or link to this item: doi:10.22028/D291-31346
Title: Unexpected Seven-Membered Ring Formation for Muraymycin-Type Nucleoside-Peptide Antibiotics
Author(s): Leyerer, Kristin
Koppermann, Stefan
Ducho, Christian
Language: English
Title: Molbank
Volume: 2020
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: muraymycins
seven-membered rings
DDC notations: 500 Science
600 Technology
610 Medicine and health
Publikation type: Journal Article
Abstract: Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents. However, the synthesis of new analogues of these natural products for structure–activity relationship (SAR) studies is challenging. In our synthetic efforts towards a muraymycin-derived nucleoside building block suitable for attachment to a solid support, we came across an interesting side product. This compound resulted from an undesired Fmoc deprotection with subsequent cyclization, thus furnishing a remarkable caprazamycin-like seven-membered diazepanone ring.
DOI of the first publication: 10.3390/M1122
Link to this record: urn:nbn:de:bsz:291--ds-313467
ISSN: 1422-8599
Date of registration: 23-Dec-2020
Description of the related object: Supplementary Materials
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Christian Ducho
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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