Bitte benutzen Sie diese Referenz, um auf diese Ressource zu verweisen: doi:10.22028/D291-30419
Titel: PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer
VerfasserIn: Hoffmann, Manuela Andrea
Buchholz, Hans-Georg
Wieler, Helmut J.
Miederer, Matthias
Rosar, Florian
Fischer, Nicolas
Müller-Hübenthal, Jonas
Trampert, Ludwin
Pektor, Stefanie
Schreckenberger, Mathias
Sprache: Englisch
Titel: Cancers
Bandnummer: 12
Heft: 2
Verlag/Plattform: MDPI
Erscheinungsjahr: 2020
Freie Schlagwörter: 68Gallium-PSMA PET/CT
prostate-specific-antigen
prostate cancer
PSA kinetics thresholds
biochemical recurrence
optimal cutoff level
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: 68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study is to determine the optimum time for performing these PET/CT scans in a large cohort of patients by identifying the prostate-specific-antigen (PSA) and PSA kinetics thresholds for detecting and localizing recurrent PC. This retrospective analysis includes 581 patients with biochemical recurrence (BC) by definition. The performance of 68Ga-PSMA-11 PET/CT in relation to the PSA value at the scan time as well as PSA kinetics was assessed by the receiver-operating-characteristic-curve (ROC) generated by plotting sensitivity versus 1-specificity. Malignant prostatic lesions were identified in 77%. For patients that were treated with radical prostatectomy (RP) a PSA value of 1.24 ng/mL was found to be the optimal cutoff level for predicting positive and negative scans, while for patients previously treated with radiotherapy (RT) it was 5.75 ng/mL. In RP-patients with PSA value <1.24 ng/mL, 52% scans were positive, whereas patients with PSA ≥1.24 ng/mL had positive scan results in 87%. RT-patients with PSA <5.75 ng/mL had positive scans in 86% and for those with PSA ≥5.75 ng/mL 94% had positive scans. This study identifies the PSA and PSA kinetics threshold levels for the presence of 68Ga-PSMA-11 PET/CT-detectable PC-lesions in BC patients.
DOI der Erstveröffentlichung: 10.3390/cancers12020398
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-304199
hdl:20.500.11880/30205
http://dx.doi.org/10.22028/D291-30419
ISSN: 2072-6694
Datum des Eintrags: 15-Dez-2020
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Radiologie
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

Dateien zu diesem Datensatz:
Datei Beschreibung GrößeFormat 
cancers-12-00398-v2.pdf1,15 MBAdobe PDFÖffnen/Anzeigen


Diese Ressource wurde unter folgender Copyright-Bestimmung veröffentlicht: Lizenz von Creative Commons Creative Commons