Please use this identifier to cite or link to this item: doi:10.22028/D291-32739
Title: Dudomycins: New Secondary Metabolites Produced after Heterologous Expression of an Nrps Cluster from Streptomyces albus ssp. Chlorinus Nrrl B-24108
Author(s): Lasch, Constanze
Stierhof, Marc
Estévez, Marta Rodríguez
Myronovskyi, Maksym
Zapp, Josef
Luzhetskyy, Andriy
Language: English
Title: Microorganisms
Volume: 8
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2020
Free key words: Streptomyces
heterologous expression
DDC notations: 500 Science
600 Technology
610 Medicine and health
Publikation type: Journal Article
Abstract: Since the 1950s, natural products of bacterial origin were systematically developed to be used as drugs with a wide range of medical applications. The available treatment options for many diseases are still not satisfying, wherefore, the discovery of new structures has not lost any of its importance. Beyond the great variety of already isolated and characterized metabolites, Streptomycetes still harbor uninvestigated gene clusters whose products can be accessed using heterologous expression in host organisms. This works presents the discovery of a set of structurally novel secondary metabolites, dudomycins A to D, through the expression of a cryptic NRPS cluster from Streptomyces albus ssp. Chlorinus NRRL B-24108 in the heterologous host strain Streptomyces albus Del14. A minimal set of genes, required for the production of dudomycins, was defined through gene inactivation experiments. This paper also proposes a model for dudomycin biosynthesis.
DOI of the first publication: 10.3390/microorganisms8111800
Link to this record: urn:nbn:de:bsz:291--ds-327398
ISSN: 2076-2607
Date of registration: 1-Dec-2020
Description of the related object: Supplementary Materials
Related object:
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Andriy Luzhetskyy
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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