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Titel: A Bifunctional Adsorber Particle for the Removal of Hydrophobic Uremic Toxins from Whole Blood of Renal Failure Patients
VerfasserIn: Sternkopf, Marieke
Thoröe-Boveleth, Sven
Beck, Tobias
Oleschko, Kirsten
Erlenkötter, Ansgar
Tschulena, Ulrich
Steppan, Sonja
Speer, Thimoteus
Goettsch, Claudia
Jankowski, Vera
Jankowski, Joachim
Noels, Heidi
The European Uremic Toxin Work Group-EUTox
Sprache: Englisch
Titel: Toxins
Bandnummer: 11
Heft: 7
Verlag/Plattform: MDPI
Erscheinungsjahr: 2019
Freie Schlagwörter: activated charcoal
hemodialysis
adsorption
uremic toxins
hemocompatibility
chronic kidney disease
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Hydrophobic uremic toxins accumulate in patients with chronic kidney disease, contributing to a highly increased cardiovascular risk. The clearance of these uremic toxins using current hemodialysis techniques is limited due to their hydrophobicity and their high binding affinity to plasma proteins. Adsorber techniques may be an appropriate alternative to increase hydrophobic uremic toxin removal. We developed an extracorporeal, whole-blood bifunctional adsorber particle consisting of a porous, activated charcoal core with a hydrophilic polyvinylpyrrolidone surface coating. The adsorption capacity was quantified using analytical chromatography after perfusion of the particles with an albumin solution or blood, each containing mixtures of hydrophobic uremic toxins. A time-dependent increase in hydrophobic uremic toxin adsorption was depicted and all toxins showed a high binding affinity to the adsorber particles. Further, the particle showed a sufficient hemocompatibility without significant effects on complement component 5a, thrombin-antithrombin III complex, or thrombocyte concentration in blood in vitro, although leukocyte counts were slightly reduced. In conclusion, the bifunctional adsorber particle with cross-linked polyvinylpyrrolidone coating showed a high adsorption capacity without adverse effects on hemocompatibility in vitro. Thus, it may be an interesting candidate for further in vivo studies with the aim to increase the efficiency of conventional dialysis techniques.
DOI der Erstveröffentlichung: 10.3390/toxins11070389
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-282424
hdl:20.500.11880/30058
http://dx.doi.org/10.22028/D291-28242
ISSN: 2072-6651
Datum des Eintrags: 19-Nov-2020
Fakultät: M - Medizinische Fakultät
Fachrichtung: M - Innere Medizin
Professur: M - Keiner Professur zugeordnet
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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