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doi:10.22028/D291-32688
Titel: | Printed Degradable Optical Waveguides for Guiding Light into Tissue |
VerfasserIn: | Feng, Jun Zheng, Yijun Bhusari, Shardul Villiou, Maria Pearson, Samuel del Campo Bécares, Aránzazu |
Sprache: | Englisch |
Titel: | Advanced functional materials |
Bandnummer: | 30 |
Heft: | 45 |
Verlag/Plattform: | Wiley |
Erscheinungsjahr: | 2020 |
Dokumenttyp: | Journalartikel / Zeitschriftenartikel |
Abstract: | Optogenetics and photonic technologies are changing the future of medicine. To implement light-based therapies in the clinic, patient-friendly devices that can deliver light inside the body while offering tunable properties and compatibility with soft tissues are needed. Here extrusion printing of degradable, hydrogel-based optical waveguides with optical losses as low as 0.1 dB cm−1 at visible wavelengths is described. Core-only and core-cladding fibers are printed at room temperature from polyethylene glycol (PEG)-based and PEG/Pluronic precursors, and cured by in situ photopolymerization. The obtained waveguides are flexible, with mechanical properties tunable within a tissue-compatible range. Degradation times are also tunable by adjusting the molar mass of the diacrylate gel precursors, which are synthesized by linking PEG diacrylate (PEGDA) with varying proportions of DL-dithiothreitol (DTT). The printed waveguides are used to activate photochemical and optogenetic processes in close-to-physiological environments. Light-triggered migration of cells in a photoresponsive 3D hydrogel and drug release from an optogenetically-engineered living material by delivering light across >5 cm of muscle tissue are demonstrated. These results quantify the in vitro performance, and reflect the potential of the printed degradable fibers for in vivo and clinical applications. |
DOI der Erstveröffentlichung: | 10.1002/adfm.202004327 |
URL der Erstveröffentlichung: | https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202004327 |
Link zu diesem Datensatz: | hdl:20.500.11880/30055 http://dx.doi.org/10.22028/D291-32688 |
ISSN: | 1616-3028 1616-301X |
Datum des Eintrags: | 18-Nov-2020 |
Fakultät: | NT - Naturwissenschaftlich- Technische Fakultät |
Fachrichtung: | NT - Chemie |
Professur: | NT - Prof. Dr. Aránzazu del Campo |
Sammlung: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
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