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Titel: Printed Degradable Optical Waveguides for Guiding Light into Tissue
VerfasserIn: Feng, Jun
Zheng, Yijun
Bhusari, Shardul
Villiou, Maria
Pearson, Samuel
del Campo Bécares, Aránzazu
Sprache: Englisch
Titel: Advanced functional materials
Bandnummer: 30
Heft: 45
Verlag/Plattform: Wiley
Erscheinungsjahr: 2020
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Optogenetics and photonic technologies are changing the future of medicine. To implement light-based therapies in the clinic, patient-friendly devices that can deliver light inside the body while offering tunable properties and compatibility with soft tissues are needed. Here extrusion printing of degradable, hydrogel-based optical waveguides with optical losses as low as 0.1 dB cm−1 at visible wavelengths is described. Core-only and core-cladding fibers are printed at room temperature from polyethylene glycol (PEG)-based and PEG/Pluronic precursors, and cured by in situ photopolymerization. The obtained waveguides are flexible, with mechanical properties tunable within a tissue-compatible range. Degradation times are also tunable by adjusting the molar mass of the diacrylate gel precursors, which are synthesized by linking PEG diacrylate (PEGDA) with varying proportions of DL-dithiothreitol (DTT). The printed waveguides are used to activate photochemical and optogenetic processes in close-to-physiological environments. Light-triggered migration of cells in a photoresponsive 3D hydrogel and drug release from an optogenetically-engineered living material by delivering light across >5 cm of muscle tissue are demonstrated. These results quantify the in vitro performance, and reflect the potential of the printed degradable fibers for in vivo and clinical applications.
DOI der Erstveröffentlichung: 10.1002/adfm.202004327
URL der Erstveröffentlichung: https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.202004327
Link zu diesem Datensatz: hdl:20.500.11880/30055
http://dx.doi.org/10.22028/D291-32688
ISSN: 1616-3028
1616-301X
Datum des Eintrags: 18-Nov-2020
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Chemie
Professur: NT - Prof. Dr. Aránzazu del Campo
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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