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Titel: Biogenic and Biomimetic Carriers as Versatile Transporters To Treat Infections
VerfasserIn: Goes, Adriely
Fuhrmann, Gregor
Sprache: Englisch
Titel: ACS infectious diseases
Bandnummer: 4
Heft: 6
Startseite: 881
Endseite: 892
Verlag/Plattform: ACS
Erscheinungsjahr: 2018
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Biogenic and biomimetic therapeutics are a relatively new class of systems that are of physiological origin and/or take advantage of natural pathways or aim at mimicking these to improve selective interaction with target tissue. The number of biogenic and bioengineered avenues for drug therapy and diagnostics has multiplied over the past years for many applications, indicating the high expectations associated with this biological route. Nevertheless, the use of "bio"-related approaches for treating or diagnosing infectious diseases is still rare. Given that infectious diseases, in particular bacterial resistances, are seriously on the rise, there is an urgent need to take advantage of biogenic and bioengineered systems to target these challenges. In this manuscript, we first give a definition of the various "bio" terms, including biogenic, biomimetic, bioinspired, and bioengineered and we highlight them using tangible applications in the field of infectious diseases. Our examples cover cell-derived systems, including bioengineered bacteria, virus-like particles, and different cell-mimetics. Moreover, we discuss natural and bioengineered particles such as extracellular vesicles from mammalian and bacterial sources and liposomes. A concluding section outlines the potential for biomaterial-related avenues to overcome challenges associated with difficult-to-treat infections. We critically discuss benefits and risks for these applications and give an outlook on the future of biogenic engineering.
DOI der Erstveröffentlichung: 10.1021/acsinfecdis.8b00030
URL der Erstveröffentlichung: https://pubs.acs.org/doi/10.1021/acsinfecdis.8b00030
Link zu diesem Datensatz: hdl:20.500.11880/30039
http://dx.doi.org/10.22028/D291-32678
ISSN: 2373-8227
Datum des Eintrags: 17-Nov-2020
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Jun.-Prof. Dr. Gregor Fuhrmann
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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