Please use this identifier to cite or link to this item: doi:10.22028/D291-27881
Title: Injectable Systems for Intra-Articular Delivery of Mesenchymal Stromal Cells for Cartilage Treatment: A Systematic Review of Preclinical and Clinical Evidence
Author(s): Roffi, Alice
Nakamura, Norimasa
Sanchez, Mikel
Cucchiarini, Magali
Filardo, Giuseppe
Language: English
Title: International Journal of Molecular Sciences
Volume: 19
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2018
Free key words: mesenchymal stromal cells
delivery vehicle
platelet-rich plasma
hyaluronic acid
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Stem cell-based therapy is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. However, the efficacy of cell injection procedures may be impaired by cell manipulation and damage as well as by cell dissemination to non-target tissues. To overcome such issues, mesenchymal stromal cell (MSC) delivery may be performed using injectable vehicles as containment systems that further provide a favorable cell microenvironment. The aim of this systematic review was to analyze the preclinical and clinical literature on platelet-rich plasma (PRP), hyaluronic acid (HA), and hydrogels for the delivery of MSCs. The systematic literature search was performed using the PubMed and Web of science databases with the following string: “(stem cells injection) AND (platelet rich plasma OR PRP OR platelet concentrate OR biomaterials OR hyaluronic acid OR hydrogels)”: 40 studies (19 preclinical and 21 clinical) met the inclusion criteria. This review revealed an increasing interest on the use of injectable agents for MSC delivery. However, while negligible adverse events and promising clinical outcomes were generally reported, the prevalence of low quality studies hinders the possibility to demonstrate the real benefits of using such injectable systems. Specific studies must be designed to clearly demonstrate the added benefits of these systems to deliver MSCs for the treatment of cartilage lesions and osteoarthritis.
DOI of the first publication: 10.3390/ijms19113322
Link to this record: urn:nbn:de:bsz:291--ds-278811
ISSN: 1422-0067
Date of registration: 12-Nov-2020
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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