Please use this identifier to cite or link to this item: doi:10.22028/D291-27915
Title: Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
Author(s): Chi, Tabughang Franklin
Horbach, Tina
Götz, Claudia
Kietzmann, Thomas
Dimova, Elitsa Y.
Language: English
Title: Cancers
Volume: 11
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: upstream stimulatory factor 2 (USF2)
cyclin-dependent kinase-5 (CDK5)
DDC notations: 570 Life sciences, biology
610 Medicine and health
Publikation type: Journal Article
Abstract: The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells.
DOI of the first publication: 10.3390/cancers11040523
Link to this record: urn:nbn:de:bsz:291--ds-279157
ISSN: 2072-6694
Date of registration: 10-Nov-2020
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biochemie und Molekularbiologie
Professorship: M - Prof. Dr. Robert Ernst
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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