Please use this identifier to cite or link to this item: doi:10.22028/D291-27880
Title: Vimentin Diversity in Health and Disease
Author(s): Danielsson, Frida
Peterson, McKenzie Kirsten
Caldeira Araújo, Helena
Lautenschläger, Franziska
Gad, Annica Karin Britt
Language: English
Title: Cells
Volume: 7
Issue: 10
Publisher/Platform: MDPI
Year of Publication: 2018
Free key words: vimentin
intermediate filaments
cell-extracellular matrix adhesions
extracellular vimentin
cell mechanical stiffness or elasticity
cellular contractility
epithelial-mesenchymal transition
tissue regeneration
cancer and metastasis
drug target
clinical biomarkers
DDC notations: 530 Physics
570 Life sciences, biology
Publikation type: Journal Article
Abstract: Vimentin is a protein that has been linked to a large variety of pathophysiological conditions, including cataracts, Crohn’s disease, rheumatoid arthritis, HIV and cancer. Vimentin has also been shown to regulate a wide spectrum of basic cellular functions. In cells, vimentin assembles into a network of filaments that spans the cytoplasm. It can also be found in smaller, non-filamentous forms that can localise both within cells and within the extracellular microenvironment. The vimentin structure can be altered by subunit exchange, cleavage into different sizes, re-annealing, post-translational modifications and interacting proteins. Together with the observation that different domains of vimentin might have evolved under different selection pressures that defined distinct biological functions for different parts of the protein, the many diverse variants of vimentin might be the cause of its functional diversity. A number of review articles have focussed on the biology and medical aspects of intermediate filament proteins without particular commitment to vimentin, and other reviews have focussed on intermediate filaments in an in vitro context. In contrast, the present review focusses almost exclusively on vimentin, and covers both ex vivo and in vivo data from tissue culture and from living organisms, including a summary of the many phenotypes of vimentin knockout animals. Our aim is to provide a comprehensive overview of the current understanding of the many diverse aspects of vimentin, from biochemical, mechanical, cellular, systems biology and medical perspectives.
DOI of the first publication: 10.3390/cells7100147
Link to this record: urn:nbn:de:bsz:291--ds-278803
ISSN: 2073-4409
Date of registration: 9-Nov-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Jun.-Prof. Dr. Franziska Lautenschläger
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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