Please use this identifier to cite or link to this item: doi:10.22028/D291-27763
Title: Increased Circulating VAP-1 Levels Are Associated with Liver Fibrosis in Chronic Hepatitis C Infection
Author(s): Kraemer, Marcel
Krawczyk, Marcin
Noor, Fozia
Grünhage, Frank
Lammert, Frank
Schneider, Jochen G.
Language: English
Title: Journal of Clinical Medicine
Volume: 8
Issue: 1
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: VAP-1
vascular adhesion protein 1
SSAO activity
semicarbazide-sensitive amino oxidase
chronic liver diseases
liver stiffness
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Vascular adhesion protein-1 (VAP-1) is a multifunction protein. While membrane-bound VAP-1 is an adhesion protein, soluble VAP-1 catalyzes the deamination of primary amines through its semicarbazide-sensitive amino oxidase (SSAO) activity. VAP-1 supports the transmigration of leukocytes and increases oxidative stress. In chronic liver diseases, it plays a role in leukocyte infiltration and fibrogenesis. Here, we measured VAP-1 plasma concentration and its SSAO activity in 322 patients with chronic hepatitis C infection and evaluated the association of VAP-1 with fibrosis stages. VAP-1 concentration strongly correlated with liver stiffness and was the second strongest influencing variable after gamma-glutamytransferase (GGT) for liver stiffness in regression analysis. The VAP-1 concentration increased with advancing fibrosis stages and the highest concentrations were found in patients with cirrhosis. According to the receiver operating characteristic (ROC) analysis, a VAP-1 cut-off value of 541 ng/mL predicted histologically confirmed cirrhosis (sensitivity 74%; specificity 72%). SSAO activity correlated only moderately with liver stiffness, showing a relatively small increase in advanced fibrosis. To our knowledge, this is the first study on VAP-1 in chronic hepatitis C infection showing its association with progressive fibrosis. In conclusion, VAP-1 plasma concentration, rather than its SSAO activity, may represent a non-invasive biomarker for monitoring fibrogenesis in patients with chronic hepatitis C infection.
DOI of the first publication: 10.3390/jcm8010103
Link to this record: urn:nbn:de:bsz:291--ds-277634
ISSN: 2077-0383
Date of registration: 3-Nov-2020
Description of the related object: Supplementary Material
Related object:
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Frank Lammert
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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