Please use this identifier to cite or link to this item: doi:10.22028/D291-32430
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Title: Prestress and Area Compressibility of Actin Cortices Determine the Viscoelastic Response of Living Cells
Author(s): Cordes, Andrea
Witt, Hannes
Gallemí-Pérez, Aina
Brückner, Bastian
Grimm, Florian
Vache, Marian
Oswald, Tabea
Bodenschatz, Jonathan
Flormann, Daniel
Lautenschläger, Franziska
Tarantola, Marco
Janshoff, Andreas
Language: English
Title: Physical review letters
Volume: 125
Issue: 6
Startpage: 1
Endpage: 5
Publisher/Platform: APS
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Shape, dynamics, and viscoelastic properties of eukaryotic cells are primarily governed by a thin, reversibly cross-linked actomyosin cortex located directly beneath the plasma membrane. We obtain time-dependent rheological responses of fibroblasts and MDCK II cells from deformation-relaxation curves using an atomic force microscope to access the dependence of cortex fluidity on prestress. We introduce a viscoelastic model that treats the cell as a composite shell and assumes that relaxation of the cortex follows a power law giving access to cortical prestress, area-compressibility modulus, and the power law exponent (fluidity). Cortex fluidity is modulated by interfering with myosin activity. We find that the power law exponent of the cell cortex decreases with increasing intrinsic prestress and area-compressibility modulus, in accordance with previous finding for isolated actin networks subject to external stress. Extrapolation to zero tension returns the theoretically predicted power law exponent for transiently cross-linked polymer networks. In contrast to the widely used Hertzian mechanics, our model provides viscoelastic parameters independent of indenter geometry and compression velocity.
DOI of the first publication: 10.1103/PhysRevLett.125.068101
URL of the first publication: https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.125.068101
Link to this record: hdl:20.500.11880/29813
http://dx.doi.org/10.22028/D291-32430
ISSN: 0031-9007
1079-7114
Date of registration: 6-Oct-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Jun.-Prof. Dr. Franziska Lautenschläger
Collections:UniBib – Die Universitätsbibliographie

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