Please use this identifier to cite or link to this item: doi:10.22028/D291-32445
Title: Adherence to Antihypertensive Drugs Assessed by Hyphenated High-Resolution Mass Spectrometry Analysis of Oral Fluids
Author(s): Lauder, Lucas
Ewen, Sebastian
Kunz, Michael
Richter, Lilian H. J.
Jacobs, Cathy M.
Kindermann, Ingrid
Böhm, Michael
Meyer, Markus R.
Mahfoud, Felix
Language: English
Title: Journal of the American Heart Association
Volume: 9
Issue: 14
Publisher/Platform: Wiley
Year of Publication: 2020
Free key words: adherence
arterial hypertension
liquid chromatography coupled to high‐resolution mass spectrometry
toxicological analyses
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Background It is currently unknown if antihypertensive drugs can be monitored in oral fluid (OF) using liquid chromatography coupled to high-resolution mass spectrometry. Methods and Results We assessed adherence using liquid chromatography coupled to high-resolution mass spectrometry in OF, plasma, and urine of 56 consecutive patients with hypertension referred to a tertiary hypertension unit. Of these patients, 59% were completely adherent (all drugs detectable in urine), whereas 29% and 13% were partially adherent (1 drug not detectable in urine) or nonadherent (>1 drug not detectable in urine), respectively. Adherent patients were on fewer antihypertensive drugs (P=0.001), had fewer daily drug doses (P=0.012), and had lower 24-hour ambulatory systolic (P=0.012) and diastolic (P=0.009) blood pressures than nonadherent or partially adherent patients. Most drugs were detected in urine compared with plasma and OF (181 versus 119 versus 88; P=0.001). Compared with urine and plasma, detection rates of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and diuretics were lower in OF. There was no difference in the frequency of detecting β blockers (P=1.0) and calcium channel blockers (P=0.063) when comparing OF with urine. There was no difference in the number of calcium channel blockers (P=0.727), β blockers (P=1.000), thiazide diuretics (P=0.125), and α-2 agonists (P=0.125) identified between OF and plasma. Conclusions This study shows the feasibility of drug adherence testing for several antihypertensive drugs, especially those without acidic components, in OF, with a similar recovery compared with plasma. Therefore, drug adherence testing in OF should be further explored as a noninvasive approach, which can easily be performed in an "out-of-office" setting.
DOI of the first publication: 10.1161/JAHA.119.014180
Link to this record: urn:nbn:de:bsz:291--ds-324458
ISSN: 2047-9980
Date of registration: 5-Oct-2020
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Professorship: M - Prof. Dr. Michael Böhm
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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