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|Title:||Adherence to Antihypertensive Drugs Assessed by Hyphenated High-Resolution Mass Spectrometry Analysis of Oral Fluids|
Richter, Lilian H. J.
Jacobs, Cathy M.
Meyer, Markus R.
|Title:||Journal of the American Heart Association|
|Year of Publication:||2020|
|Free key words:||adherence|
liquid chromatography coupled to high‐resolution mass spectrometry
|DDC notations:||610 Medicine and health|
|Publikation type:||Journal Article|
|Abstract:||Background It is currently unknown if antihypertensive drugs can be monitored in oral fluid (OF) using liquid chromatography coupled to high-resolution mass spectrometry. Methods and Results We assessed adherence using liquid chromatography coupled to high-resolution mass spectrometry in OF, plasma, and urine of 56 consecutive patients with hypertension referred to a tertiary hypertension unit. Of these patients, 59% were completely adherent (all drugs detectable in urine), whereas 29% and 13% were partially adherent (1 drug not detectable in urine) or nonadherent (>1 drug not detectable in urine), respectively. Adherent patients were on fewer antihypertensive drugs (P=0.001), had fewer daily drug doses (P=0.012), and had lower 24-hour ambulatory systolic (P=0.012) and diastolic (P=0.009) blood pressures than nonadherent or partially adherent patients. Most drugs were detected in urine compared with plasma and OF (181 versus 119 versus 88; P=0.001). Compared with urine and plasma, detection rates of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and diuretics were lower in OF. There was no difference in the frequency of detecting β blockers (P=1.0) and calcium channel blockers (P=0.063) when comparing OF with urine. There was no difference in the number of calcium channel blockers (P=0.727), β blockers (P=1.000), thiazide diuretics (P=0.125), and α-2 agonists (P=0.125) identified between OF and plasma. Conclusions This study shows the feasibility of drug adherence testing for several antihypertensive drugs, especially those without acidic components, in OF, with a similar recovery compared with plasma. Therefore, drug adherence testing in OF should be further explored as a noninvasive approach, which can easily be performed in an "out-of-office" setting.|
|DOI of the first publication:||10.1161/JAHA.119.014180|
|Link to this record:||urn:nbn:de:bsz:291--ds-324458|
|Date of registration:||5-Oct-2020|
|Faculty:||M - Medizinische Fakultät|
|Department:||M - Innere Medizin|
|Professorship:||M - Prof. Dr. Michael Böhm|
|Collections:||SciDok - Der Wissenschaftsserver der Universität des Saarlandes|
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