Please use this identifier to cite or link to this item: doi:10.22028/D291-32369
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Title: Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion
Author(s): Villiou, Maria
Paez, Julieta I.
del Campo Bécares, Aránzazu
Language: English
Title: ACS applied materials & interfaces
Volume: 12
Issue: 34
Startpage: 37862
Endpage: 37872
Publisher/Platform: ACS
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Hydrogels for wound management and tissue gluing applications have to adhere to tissues for a given time scale and then disappear, either by removal from the skin or by slow degradation for applications inside the body. Advanced wound management materials also envision the encapsulation of therapeutic drugs or cells to support the natural healing process. The design of hydrogels that can fulfill all of these properties with minimal chemical complexity, a stringent condition to favor transfer into a real medical device, is challenging. Herein, we present a hydrogel design with a moderate structural complexity that fulfills a number of relevant properties for wound dressing: it can form in situ and encapsulate cells, it can adhere to tissues, and it can be degraded on demand by light exposure under cytocompatible conditions. The hydrogels are based on starPEG macromers terminated with catechol groups as cross-linking units and contain intercalated photocleavable nitrobenzyl triazole groups. Hydrogels are formed under mild conditions (N-(2-hydroxyethyl)piperazine-N′-ethanesulfonic acid (HEPES) buffer with 9–18 mM sodium periodate as the oxidant) and are compatible with encapsulated cells. Upon light irradiation, the cleavage of the nitrobenzyl group mediates depolymerization, which enables the on-demand release of cells and debonding from tissues. The molecular design and obtained properties reported here are interesting for the development of advanced wound dressings and cell therapies and expand the range of functionality of current alternatives.
DOI of the first publication: 10.1021/acsami.0c08568
URL of the first publication: https://pubs.acs.org/doi/abs/10.1021/acsami.0c08568
Link to this record: hdl:20.500.11880/29751
http://dx.doi.org/10.22028/D291-32369
ISSN: 1944-8244
1944-8252
Date of registration: 28-Sep-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:UniBib – Die Universitätsbibliographie

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