Please use this identifier to cite or link to this item: doi:10.22028/D291-31902
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Title: Ultrathin Homogenous AuNP Monolayers as Tunable Functional Substrates for Surface-Assisted Laser Desorption/Ionization of Small Biomolecules
Author(s): Liu, Zhen
Zhang, Peng
Kister, Thomas
Kraus, Tobias
Volmer, Dietrich A.
Language: English
Title: Journal of the American Society for Mass Spectrometry : JASMS online
Volume: 31
Issue: 1
Startpage: 47
Endpage: 57
Publisher/Platform: ACS
Year of Publication: 2019
Publikation type: Journal Article
Abstract: A series of ultrathin, homogenous gold nanoparticle (AuNP) substrates for surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) were prepared using a simple air/water interface approach. These SALDI substrates enabled soft ionization and provided significant improvements in terms of signal intensities and reduced background levels in comparison to other AuNP morphologies for different analytes such as fatty acids, peptides, amino acids, saccharides, and drugs. Through different microscopic and spectroscopic methods, we determined that the packing homogeneity of the [AuNP]n substrates played a vital role in the efficiency of the SALDI process. We demonstrated that the signal intensities of the investigated analytes were readily optimized by manipulating the thickness of the [AuNP]n substrates. The desorption/ionization efficiency increased as a function of the number of layers and then reached a saturation point. The optimized [AuNP]n substrates not only exhibited high SALDI-MS desorption/ionization efficiencies but also showed excellent reproducibilities of the analyte signals.
DOI of the first publication: 10.1021/jasms.9b00038
URL of the first publication:
Link to this record: hdl:20.500.11880/29530
ISSN: 1044-0305
Date of registration: 17-Aug-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Tobias Kraus
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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