Please use this identifier to cite or link to this item: doi:10.22028/D291-30953
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Title: Molecular insight into specific 14-3-3 modulators: Inhibitors and stabilisers of protein-protein interactions of 14-3-3
Author(s): Hartman, Alwin M.
Hirsch, Anna
Language: English
Title: European journal of medicinal chemistry
Volume: 136
Startpage: 573
Endpage: 584
Publisher/Platform: Elsevier
Year of Publication: 2017
Publikation type: Journal Article
Abstract: The 14-3-3 protein family is implicated in several diseases and biological processes. Several recent reviews have summarised knowledge on certain aspects of 14-3-3 proteins, ranging from a historic overview to the structure, function and regulation. This review focuses on the structures and molecular recognition of the modulators by the 14-3-3 proteins, and small modifications of certain modulators are proposed where cocrystal structures have been reported. Our analysis opens up possibilities for the optimisation of the reported compounds. It is very timely to analyse the current status of recently developed modulators given that the field has seen a lot of activity in recent years. This review provides an overview combined with a critical analysis of each class of modulators, keeping their suitability for future development in mind.
DOI of the first publication: 10.1016/j.ejmech.2017.04.058
URL of the first publication:
Link to this record: hdl:20.500.11880/29160
ISSN: 1768-3254
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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