Please use this identifier to cite or link to this item: doi:10.22028/D291-30950
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Title: Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs
Author(s): Nasti, Rita
Rossi, Daniela
Amadio, Marialaura
Pascale, Alessia
Unver, M. Yagiz
Hirsch, Anna
Collina, Simona
Language: English
Title: Journal of medicinal chemistry
Volume: 60
Issue: 20
Startpage: 8257
Endpage: 8267
Publisher/Platform: ACS
Year of Publication: 2017
Publikation type: Journal Article
Abstract: RNA-binding proteins play a key role in post-transcriptional processes. Among these proteins, embryonic lethal abnormal vision (ELAV) proteins are among the best described. ELAV proteins predominantly act as positive regulators of gene expression, and their dysregulation is involved in several pathologies, such as cancer, inflammation, and neurodegenerative diseases. Only a few structurally unrelated compounds interfering with ELAV protein-mRNA complexes have been identified by applying high-throughput screening approaches. Considering the structural diversity of the compounds discovered so far and the different techniques employed for screening their ability to interfere with ELAV protein-mRNA complexes, drawing conclusions from structure-activity relationships remains a challenge. We performed docking studies to understand the interactions of compounds reported over the past decade to be inhibitors of ELAV proteins and to evaluate the potential of computer-aided drug design to target this family of proteins for further drug discovery.
DOI of the first publication: 10.1021/acs.jmedchem.6b01871
URL of the first publication: https://pubs.acs.org/doi/10.1021/acs.jmedchem.6b01871
Link to this record: hdl:20.500.11880/29158
http://dx.doi.org/10.22028/D291-30950
ISSN: 1520-4804
0022-2623
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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