Please use this identifier to cite or link to this item: doi:10.22028/D291-30947
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Title: Dynamic Proteoids Generated From Dipeptide-Based Monomers
Author(s): Liu, Yun
Stuart, Marc C. A.
Buhler, Eric
Hirsch, Anna
Language: English
Title: Macromolecular rapid communications : MRC
Volume: 39
Issue: 13
Startpage: 1
Endpage: 5
Publisher/Platform: Wiley-VCH
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Dynamic proteoids are dynamic covalent analogues of proteins which are generated through the reversible polymerization of amino-acid- or peptide-derived monomers. The authors design and prepare a series of dynamic proteoids based on the reversible polycondensation of six types of dipeptide hydrazides bearing different categories of side chains. The polymerization and structures of biodynamers generated by 1 H-NMR spectroscopy, light scattering and cryo-transmission-electron microscopy are studied. This study shows that the presence of aromatic rings in the side chains plays the most essential role in determining the extent of the polymerization and organization into resultant nanostructures through π-π-stacking interactions, hydroxyl groups have a less favorable influence via hydrogen bonds, whereas a high density of positive charge blocks the generation of biodynamers due to electrostatic repulsions. These findings set the stage for the rational design and synthesis of dynamic proteoids as novel biofunctional materials.
DOI of the first publication: 10.1002/marc.201800099
URL of the first publication: https://onlinelibrary.wiley.com/doi/abs/10.1002/marc.201800099
Link to this record: hdl:20.500.11880/29156
http://dx.doi.org/10.22028/D291-30947
ISSN: 1521-3927
1022-1336
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:UniBib – Die Universitätsbibliographie

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