Please use this identifier to cite or link to this item: doi:10.22028/D291-30945
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Title: Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments
Author(s): Łozińska, Iwona
Świerczyńska, Aleksandra
Molęda, Zuzanna
Hartman, Alwin M.
Hirsch, Anna
Czarnocki, Zbigniew
Language: English
Title: Archiv der Pharmazie : chemistry in life sciences
Volume: 351
Issue: 11
Publisher/Platform: Wiley-Blackwell
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Hybrid inhibitors of acetyl- and butyrylcholinesterase are compounds that combine structural motifs of two different classical inhibitors, leading to a dual binding ligand. A rapidly growing collection of those compounds involves a wide diversity of structural motifs, but the way of linking two active fragments and its impact on the affinity toward cholinesterases usually remains beyond the extent of investigation. We present hereby a detailed analysis of this aspect using melatonin-donepezil hybrids. A new series of compounds, in which two fragments are connected using a carbamate linker, exhibits excellent activity and selectivity toward butyrylcholinesterase.
DOI of the first publication: 10.1002/ardp.201800194
URL of the first publication:
Link to this record: hdl:20.500.11880/29155
ISSN: 0365-6233
Date of registration: 15-May-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Anna Hirsch
Collections:Die Universitätsbibliographie

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