Please use this identifier to cite or link to this item: doi:10.22028/D291-29367
Title: Protein Kinase CK2—A Putative Target for the Therapy of Diabetes Mellitus?
Author(s): Ampofo, Emmanuel
Nalbach, Lisa
Menger, Michael D.
Montenarh, Mathias
Götz, Claudia
Language: English
Title: International Journal of Molecular Sciences
Volume: 20
Issue: 18
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: CK2
diabetes
β-cells
insulin
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Since diabetes is a global epidemic, the development of novel therapeutic strategies for the treatment of this disease is of major clinical interest. Diabetes is differentiated in two types: type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). T1DM arises from an autoimmune destruction of insulin-producing β-cells whereas T2DM is characterized by an insulin resistance, an impaired insulin reaction of the target cells, and/or dysregulated insulin secretion. In the past, a growing number of studies have reported on the important role of the protein kinase CK2 in the regulation of the survival and endocrine function of pancreatic β-cells. In fact, inhibition of CK2 is capable of reducing cytokine-induced loss of β-cells and increases insulin expression as well as secretion by various pathways that are regulated by reversible phosphorylation of proteins. Moreover, CK2 inhibition modulates pathways that are involved in the development of diabetes and prevents signal transduction, leading to late complications such as diabetic retinopathy. Hence, targeting CK2 may represent a novel therapeutic strategy for the treatment of diabetes.
DOI of the first publication: 10.3390/ijms20184398
Link to this record: urn:nbn:de:bsz:291--ds-293673
hdl:20.500.11880/28948
http://dx.doi.org/10.22028/D291-29367
ISSN: 1422-0067
Date of registration: 5-Apr-2020
Faculty: M - Medizinische Fakultät
Department: M - Chirurgie
M - Medizinische Biochemie und Molekularbiologie
Professorship: M - Prof. Dr. Michael D. Menger
M - Prof. Dr. Gerald Thiel
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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