Please use this identifier to cite or link to this item: doi:10.22028/D291-28001
Title: Connexins and Gap Junctions in Cancer of the Urinary Tract
Author(s): Tschernig, Thomas
Language: English
Title: Cancers
Volume: 11
Issue: 5
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: connexins
gap junctions
intercellular communication
human urinary tract
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: This review focuses on connexins and nexus or gap junctions in the genesis, progression, and therapy of carcinomas of the human urinary tract. Some decades ago, the idea was born that gap junctional intercellular communication might prevent both the onset and the progression of cancer. Later evidence indicated that, on the contrary, synthesis and the presence of connexins as a prerequisite for gap junctional intercellular communication might promote the occurrence of cancer and metastases. The research history of urinary bladder cancer is a good example of the development of scientific perception. So far, the role of gap junctional intercellular communication in carcinogenesis and cancer progression, as well as in therapeutical approaches, remains unclear.
DOI of the first publication: 10.3390/cancers11050704
Link to this record: urn:nbn:de:bsz:291--ds-280014
ISSN: 2072-6694
Date of registration: 5-Apr-2020
Faculty: M - Medizinische Fakultät
Department: M - Anatomie und Zellbiologie
Professorship: M - Prof. Dr. Carola Meier
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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