Please use this identifier to cite or link to this item: doi:10.22028/D291-27911
Title: STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment
Author(s): Frisch, Janina
Angenendt, Adrian
Hoth, Markus
Prates Roma, Leticia
Lis, Annette
Language: English
Title: Cancers
Volume: 11
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2019
Free key words: Orai
reactive oxygen species
tumor microenvironment
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: The tumor microenvironment (TME) is shaped by cancer and noncancerous cells, the extracellular matrix, soluble factors, and blood vessels. Interactions between the cells, matrix, soluble factors, and blood vessels generate this complex heterogeneous microenvironment. The TME may be metabolically beneficial or unbeneficial for tumor growth, it may favor or not favor a productive immune response against tumor cells, or it may even favor conditions suited to hijacking the immune system for benefitting tumor growth. Soluble factors relevant for TME include oxygen, reactive oxygen species (ROS), ATP, Ca2+, H+, growth factors, or cytokines. Ca2+ plays a prominent role in the TME because its concentration is directly linked to cancer cell proliferation, apoptosis, or migration but also to immune cell function. Stromal-interaction molecules (STIM)-activated Orai channels are major Ca2+ entry channels in cancer cells and immune cells, they are upregulated in many tumors, and they are strongly regulated by ROS. Thus, STIM and Orai are interesting candidates to regulate cancer cell fate in the TME. In this review, we summarize the current knowledge about the function of ROS and STIM/Orai in cancer cells; discuss their interdependencies; and propose new hypotheses how TME, ROS, and Orai channels influence each other.
DOI of the first publication: 10.3390/cancers11040457
Link to this record: urn:nbn:de:bsz:291--ds-279111
ISSN: 2072-6694
Date of registration: 30-Mar-2020
Faculty: M - Medizinische Fakultät
Department: M - Biophysik
Professorship: M - Prof. Dr. Markus Hoth
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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