Please use this identifier to cite or link to this item: doi:10.22028/D291-27460
Title: Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease
Author(s): Grimm, Marcus Otto Walter
Regner, Liesa
Mett, Janine
Stahlmann, Christoph P.
Schorr, Pascal
Nelke, Christopher
Streidenberger, Olga
Stoetzel, Hannah
Winkler, Jakob
Zaidan, Shatha R.
Thiel, Andrea
Endres, Kristina
Grimm, Heike S.
Volmer, Dietrich A.
Hartmann, Tobias
Language: English
Title: International Journal of Molecular Sciences
Volume: 17
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2016
Free key words: tocotrienol
vitamin E
Alzheimer´s disease
amyloid-β
tocopherol
Aβ degradation
β-secretase
γ-secretase
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with a reduced risk of AD due to its antioxidative properties. However, epidemiological studies and nutritional approaches of vitamin E treatment are controversial. Here, we investigate the effect of α-tocotrienol, which belongs to the group of vitamin E, on AD-relevant processes in neuronal cell lines. In line with the literature, α-tocotrienol reduced the ROS level in SH-SY5Y cells. In the presence of tocotrienols, cholesterol and cholesterol esters, which have been shown to be risk factors in AD, were decreased. Besides the unambiguous positive effects of tocotrienol, amyloid-β (Aβ) levels were increased accompanied by an increase in the activity of enzymes responsible for Aβ production. Proteins and gene expression of the secretases and their components remained unchanged, whereas tocotrienol accelerates enzyme activity in cell-free assays. Besides enhanced Aβ production, tocotrienols inhibited Aβ degradation in neuro 2a (N2a)-cells. Our results might help to understand the controversial findings of vitamin E studies and demonstrate that besides the known positive neuroprotective properties, tocotrienols also have negative characteristics with respect to AD.
DOI of the first publication: 10.3390/ijms17111809
Link to this record: urn:nbn:de:bsz:291--ds-274609
hdl:20.500.11880/28922
http://dx.doi.org/10.22028/D291-27460
ISSN: 1422-0067
Date of registration: 27-Mar-2020
Faculty: M - Medizinische Fakultät
Department: M - Neurologie und Psychiatrie
Professorship: M - Keiner Professur zugeordnet
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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