Please use this identifier to cite or link to this item: doi:10.22028/D291-30523
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Title: Community-Associated Staphylococcus aureus from Sub-Saharan Africa and Germany: A Cross-Sectional Geographic Correlation Study
Author(s): Ruffing, Ulla
Alabi, Abraham
Kazimoto, Theckla
Vubil, Delfino C.
Akulenko, Ruslan
Abdulla, Salim
Alonso, Pedro
Bischoff, Markus
Germann, Anja
Grobusch, Martin P.
Helms, Volkhard
Hoffmann, Jonas
Kern, Winfried V.
Kremsner, Peter G.
Mandomando, Inacio
Mellmann, Alexander
Peters, Georg
Schaumburg, Frieder
Schubert, Sabine
Strauß, Lena
Tanner, Marcel
Briesen, Hagen von
Wende, Laura
Müller, Lutz von
Herrmann, Mathias
Language: English
Title: Scientific reports
Volume: 7
Issue: 1
Publisher/Platform: Nature Publishing Group
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Clonal clusters and gene repertoires of Staphylococcus aureus are essential to understand disease and are well characterized in industrialized countries but poorly analysed in developing regions. The objective of this study was to compare the molecular-epidemiologic profiles of S. aureus isolates from Sub-Saharan Africa and Germany. S. aureus isolates from 600 staphylococcal carriers and 600 patients with community-associated staphylococcal disease were characterized by DNA hybridization, clonal complex (CC) attribution, and principal component (PCA)-based gene repertoire analysis. 73% of all CCs identified representing 77% of the isolates contained in these CCs were predominant in either African or German region. Significant differences between African versus German isolates were found for alleles encoding the accessory gene regulator type, enterotoxins, the Panton-Valentine leukocidin, immune evasion gene cluster, and adhesins. PCA in conjunction with silhouette analysis distinguished nine separable PCA clusters, with five clusters primarily comprising of African and two clusters of German isolates. Significant differences between S. aureus lineages in Africa and Germany may be a clue to explain the apparent difference in disease between tropical/(so-called) developing and temperate/industrialized regions. In low-resource countries further clinical-epidemiologic research is warranted not only for neglected tropical diseases but also for major bacterial infections.
DOI of the first publication: 10.1038/s41598-017-00214-8
URL of the first publication: https://www.nature.com/articles/s41598-017-00214-8
Link to this record: hdl:20.500.11880/28899
http://dx.doi.org/10.22028/D291-30523
ISSN: 2045-2322
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:UniBib – Die Universitätsbibliographie

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