Please use this identifier to cite or link to this item: doi:10.22028/D291-30521
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Title: Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare
Author(s): Will, Thorsten
Helms, Volkhard
Language: English
Title: BMC systems biology
Volume: 11
Issue: 1
Publisher/Platform: BioMed Central
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Differential analysis of cellular conditions is a key approach towards understanding the consequences and driving causes behind biological processes such as developmental transitions or diseases. The progress of whole-genome expression profiling enabled to conveniently capture the state of a cell's transcriptome and to detect the characteristic features that distinguish cells in specific conditions. In contrast, mapping the physical protein interactome for many samples is experimentally infeasible at the moment. For the understanding of the whole system, however, it is equally important how the interactions of proteins are rewired between cellular states. To overcome this deficiency, we recently showed how condition-specific protein interaction networks that even consider alternative splicing can be inferred from transcript expression data. Here, we present the differential network analysis tool PPICompare that was specifically designed for isoform-sensitive protein interaction networks.
DOI of the first publication: 10.1186/s12918-017-0400-x
URL of the first publication: https://bmcsystbiol.biomedcentral.com/articles/10.1186/s12918-017-0400-x
Link to this record: hdl:20.500.11880/28897
http://dx.doi.org/10.22028/D291-30521
ISSN: 1752-0509
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:UniBib – Die Universitätsbibliographie

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