Please use this identifier to cite or link to this item: doi:10.22028/D291-30516
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Title: An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases
Author(s): Lang, Sven
Pfeffer, Stefan
Lee, Po-Hsien
Cavalié, Adolfo
Helms, Volkhard
Förster, Friedrich
Zimmermann, Richard
Language: English
Title: Frontiers in physiology
Volume: 8
Startpage: 1
Endpage: 22
Publisher/Platform: Frontiers Research Foundation
Year of Publication: 2017
Publikation type: Journal Article
Abstract: The membrane of the endoplasmic reticulum (ER) of nucleated human cells harbors the protein translocon, which facilitates membrane integration or translocation of almost every newly synthesized polypeptide targeted to organelles of the endo- and exocytotic pathway. The translocon comprises the polypeptide-conducting Sec61 channel and several additional proteins and complexes that are permanently or transiently associated with the heterotrimeric Sec61 complex. This ensemble of proteins facilitates ER targeting of precursor polypeptides, modification of precursor polypeptides in transit through the Sec61 complex, and Sec61 channel gating, i.e., dynamic regulation of the pore forming subunit to mediate precursor transport and calcium efflux. Recently, cryoelectron tomography of translocons in native ER membrane vesicles, derived from human cell lines or patient fibroblasts, and even intact cells has given unprecedented insights into the architecture and dynamics of the native translocon and the Sec61 channel. These structural data are discussed in light of different Sec61 channel activities including ribosome receptor function, membrane insertion, and translocation of newly synthesized polypeptides as well as the putative physiological roles of the Sec61 channel as a passive ER calcium leak channel. Furthermore, the structural insights into the Sec61 channel are incorporated into an overview and update on Sec61 channel-related diseases-the Sec61 channelopathies-and novel therapeutic concepts for their treatment.
DOI of the first publication: 10.3389/fphys.2017.00887
URL of the first publication: https://www.frontiersin.org/articles/10.3389/fphys.2017.00887/full
Link to this record: hdl:20.500.11880/28893
http://dx.doi.org/10.22028/D291-30516
ISSN: 1664-042X
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:UniBib – Die Universitätsbibliographie

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