Please use this identifier to cite or link to this item: doi:10.22028/D291-30515
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Title: MutaNET: a tool for automated analysis of genomic mutations in gene regulatory networks
Author(s): Hollander, Markus
Hamed, Mohamed
Helms, Volkhard
Neininger, Kerstin
Language: English
Title: Bioinformatics
Volume: 34
Issue: 5
Startpage: 864
Endpage: 866
Publisher/Platform: Oxford University Press
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Mutations in genomic key elements can influence gene expression and function in various ways, and hence greatly contribute to the phenotype. We developed MutaNET to score the impact of individual mutations on gene regulation and function of a given genome. MutaNET performs statistical analyses of mutations in different genomic regions. The tool also incorporates the mutations in a provided gene regulatory network to estimate their global impact. The integration of a next-generation sequencing pipeline enables calling mutations prior to the analyses. As application example, we used MutaNET to analyze the impact of mutations in antibiotic resistance (AR) genes and their potential effect on AR of bacterial strains.
DOI of the first publication: 10.1093/bioinformatics/btx687
URL of the first publication: https://academic.oup.com/bioinformatics/article/34/5/864/4566178
Link to this record: hdl:20.500.11880/28892
http://dx.doi.org/10.22028/D291-30515
ISSN: 1460-2059
1367-4811
1367-4803
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:UniBib – Die Universitätsbibliographie

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