Please use this identifier to cite or link to this item: doi:10.22028/D291-30501
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Title: ER import of small human presecretory proteins: components and mechanisms
Author(s): Haßdenteufel, Sarah
Nguyen, Duy
Helms, Volkhard
Lang, Sven
Zimmermann, Richard
Language: English
Title: FEBS letters : for the rapid publication of short reports in biochemistry, biophysics, and molecular biology
Volume: 593
Issue: 18
Startpage: 2506
Endpage: 2524
Publisher/Platform: Wiley
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Protein transport into the mammalian endoplasmic reticulum (ER) used to be seen as strictly cotranslational, that is temporarily and mechanistically coupled to protein synthesis. In the course of the last decades, however, several classes of precursors of soluble and membrane proteins were found to be post-translationally imported into the ER, without any involvement of the ribosome. The first such class to be identified were the small presecretory proteins; tail-anchored membrane proteins followed next. In both classes, the inherent address tag is released from the translating ribosome before the initiation of ER import, as part of the fully synthesized precursor. In small presecretory proteins, the information for ER targeting and -translocation via the polypeptide-conducting Sec61-channel is encoded by a classical N-terminal signal peptide, which is released from the ribsosome before targeting due to the small size of the full-length precursor. Here, we discuss the current state of research on targeting and translocation of small presecretory proteins into the mammalian ER. In closing, we present a unifying hypothesis for ER protein translocation in terms of an energy diagram for Sec61-channel gating.
DOI of the first publication: 10.1002/1873-3468.13542
URL of the first publication:
Link to this record: hdl:20.500.11880/28881
ISSN: 1873-3468
Date of registration: 20-Mar-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:UniBib – Die Universitätsbibliographie

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