Please use this identifier to cite or link to this item: doi:10.22028/D291-30412
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Title: miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database
Author(s): Kehl, Tim
Kern, Fabian
Backes, Christina
Fehlmann, Tobias
Stöckel, Daniel
Meese, Eckart
Lenhof, Hans-Peter
Keller, Andreas
Language: English
Title: Nucleic acids research
Volume: 48
Issue: D1
Startpage: D142
Endpage: D147
Publisher/Platform: Oxford University Press
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Since the initial release of miRPathDB, tremendous progress has been made in the field of microRNA (miRNA) research. New miRNA reference databases have emerged, a vast amount of new miRNA candidates has been discovered and the number of experimentally validated target genes has increased considerably. Hence, the demand for a major upgrade of miRPathDB, including extended analysis functionality and intuitive visualizations of query results has emerged. Here, we present the novel release 2.0 of the miRNA Pathway Dictionary Database (miRPathDB) that is freely accessible at https://mpd.bioinf.uni-sb.de/. miRPathDB 2.0 comes with a ten-fold increase of pre-processed data. In total, the updated database provides putative associations between 27 452 (candidate) miRNAs, 28 352 targets and 16 833 pathways for Homo sapiens, as well as interactions of 1978 miRNAs, 24 898 targets and 6511 functional categories for Mus musculus. Additionally, we analyzed publications citing miRPathDB to identify common use-cases and further extensions. Based on this evaluation, we added new functionality for interactive visualizations and down-stream analyses of bulk queries. In summary, the updated version of miRPathDB, with its new custom-tailored features, is one of the most comprehensive and advanced resources for miRNAs and their target pathways.
DOI of the first publication: 10.1093/nar/gkz1022
URL of the first publication: https://academic.oup.com/nar/article/48/D1/D142/5613673
Link to this record: hdl:20.500.11880/28819
http://dx.doi.org/10.22028/D291-30412
ISSN: 1362-4962
0305-1048
1362-4954
Date of registration: 2-Mar-2020
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Hans-Peter Lenhof
Collections:UniBib – Die Universitätsbibliographie

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