Please use this identifier to cite or link to this item: doi:10.22028/D291-30415
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Title: SUMO pathway inhibition targets an aggressive pancreatic cancer subtype
Author(s): Biederstädt, Alexander
Hassan, Zonera
Schneeweis, Christian
Schick, Markus
Schneider, Lara
Muckenhuber, Alexander
Hong, Yingfen
Siegers, Gerrit
Nilsson, Lisa
Wirth, Matthias
Dantes, Zahra
Steiger, Katja
Schunck, Kathrin
Langston, Steve
Lenhof, Hans-Peter
Coluccio, Andrea
Orben, Felix
Slawska, Jolanta
Scherger, Anna
Saur, Dieter
Müller, Stefan
Rad, Roland
Weichert, Wilko
Nilsson, Jonas
Reichert, Maximilian
Schneider, Günter
Keller, Ulrich
Language: English
Title: Gut : an international journal of gastroenterology and hepatology
Startpage: 1
Endpage: 11
Publisher/Platform: BMJ Publishing Group
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Pancreatic ductal adenocarcinoma (PDAC) still carries a dismal prognosis with an overall 5-year survival rate of 9%. Conventional combination chemotherapies are a clear advance in the treatment of PDAC; however, subtypes of the disease exist, which exhibit extensive resistance to such therapies. Genomic MYC amplifications represent a distinct subset of PDAC with an aggressive tumour biology. It is clear that hyperactivation of MYC generates dependencies that can be exploited therapeutically. The aim of the study was to find and to target MYC-associated dependencies.
DOI of the first publication: 10.1136/gutjnl-2018-317856
URL of the first publication:
Link to this record: hdl:20.500.11880/28817
ISSN: 1468-3288
Date of registration: 2-Mar-2020
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Hans-Peter Lenhof
Collections:UniBib – Die Universitätsbibliographie

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