Please use this identifier to cite or link to this item: doi:10.22028/D291-30118
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Title: Deterministic actin waves as generators of cell polarization cues
Author(s): Stankevicins, Luiza
Hecker, Jan-Nicolas Maria
Terriac, Emmanuel
Maiuri, Paolo
Schoppmeyer, Rouven
Vargas, Pablo
Lennon-Duménil, Ana-Maria
Piel, Matthieu
Qu, Bin
Hoth, Markus
Kruse, Karsten
Lautenschläger, Franziska
Language: English
Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 117
Issue: 2
Startpage: 826
Endpage: 835
Publisher/Platform: National Academy of Sciences
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Dendritic cells "patrol" the human body to detect pathogens. In their search, dendritic cells perform a random walk by amoeboid migration. The efficiency of pathogen detection depends on the properties of the random walk. It is not known how the dendritic cells control these properties. Here, we quantify dendritic cell migration under well-defined 2-dimensional confinement and in a 3-dimensional collagen matrix through recording their long-term trajectories. We find 2 different migration states: persistent migration, during which the dendritic cells move along curved paths, and diffusive migration, which is characterized by successive sharp turns. These states exhibit differences in the actin distributions. Our theoretical and experimental analyses indicate that this kind of motion can be generated by spontaneous actin polymerization waves that contribute to dendritic cell polarization and migration. The relative distributions of persistent and diffusive migration can be changed by modification of the molecular actin filament nucleation and assembly rates. Thus, dendritic cells can control their migration patterns and adapt to specific environments. Our study offers an additional perspective on how dendritic cells tune their searches for pathogens.
DOI of the first publication: 10.1073/pnas.1907845117
URL of the first publication: https://www.pnas.org/content/117/2/826
Link to this record: hdl:20.500.11880/28752
http://dx.doi.org/10.22028/D291-30118
ISSN: 1091-6490
0027-8424
Date of registration: 20-Feb-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Jun.-Prof. Dr. Franziska Lautenschläger
Collections:UniBib – Die Universitätsbibliographie

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