Please use this identifier to cite or link to this item: doi:10.22028/D291-30343
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Title: Modulation of intracellular calcium signaling by microRNA-34a-5p
Author(s): Diener, Caroline
Hart, Martin
Alansary, Dalia
Poth, Vanessa
Walch-Rückheim, Barbara
Menegatti, Jennifer
Grässer, Friedrich
Fehlmann, Tobias
Rheinheimer, Stefanie
Niemeyer, Barbara A.
Lenhof, Hans-Peter
Keller, Andreas
Meese, Eckart
Language: English
Title: Cell death & disease
Volume: 9
Issue: 10
Startpage: 1
Endpage: 13
Publisher/Platform: Nature Publishing Group
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Adjusting intracellular calcium signaling is an important feature in the regulation of immune cell function and survival. Here we show that miR-34a-5p, a small non-coding RNA that is deregulated in many common diseases, is a regulator of store-operated Ca2+ entry (SOCE) and calcineurin signaling. Upon miR-34a-5p overexpression, we observed both a decreased depletion of ER calcium content and a decreased Ca2+ influx through Ca2+ release-activated Ca2+ channels. Based on an in silico target prediction we identified multiple miR-34a-5p target genes within both pathways that are implicated in the balance between T-cell activation and apoptosis including ITPR2, CAMLG, STIM1, ORAI3, RCAN1, PPP3R1, and NFATC4. Functional analysis revealed a decrease in Ca2+ activated calcineurin pathway activity measured by a reduced IL-2 secretion due to miR-34a-5p overexpression. Impacting SOCE and/or downstream calcineurin/NFAT signaling by miR-34a-5p offers a possible future approach to manipulate immune cells for clinical interventions.
DOI of the first publication: 10.1038/s41419-018-1050-7
URL of the first publication:
Link to this record: hdl:20.500.11880/28749
ISSN: 2041-4889
Date of registration: 20-Feb-2020
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Hans-Peter Lenhof
Collections:UniBib – Die Universitätsbibliographie

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