Please use this identifier to cite or link to this item: doi:10.22028/D291-27505
Title: PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine—An Overview
Author(s): Rey-Rico, Ana
Cucchiarini, Magali
Language: English
Title: International Journal of Molecular Sciences
Volume: 19
Issue: 3
Endpage: MDPI
Year of Publication: 2018
Free key words: PEO-PPO-PEO copolymers
nonviral vectors
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of “smart” or “intelligent” systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches.
DOI of the first publication: 10.3390/ijms19030775
Link to this record: urn:nbn:de:bsz:291--ds-275055
ISSN: 1422-0067
Date of registration: 12-Feb-2020
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Professorship: M - Prof. Dr. Henning Madry
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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