Please use this identifier to cite or link to this item: doi:10.22028/D291-30211
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Title: About miRNAs, miRNA seeds, target genes and target pathways
Author(s): Kehl, Tim
Backes, Christina
Kern, Fabian
Fehlmann, Tobias
Ludwig, Nicole
Meese, Eckart
Lenhof, Hans-Peter
Keller, Andreas
Language: English
Title: OncoTarget : open access impact journal
Volume: 8
Issue: 63
Startpage: 107167
Endpage: 107175
Publisher/Platform: Impact Journals LLC
Year of Publication: 2017
Publikation type: Journal Article
Abstract: miRNAs are typically repressing gene expression by binding to the 3' UTR, leading to degradation of the mRNA. This process is dominated by the eight-base seed region of the miRNA. Further, miRNAs are known not only to target genes but also to target significant parts of pathways. A logical line of thoughts is: miRNAs with similar (seed) sequence target similar sets of genes and thus similar sets of pathways. By calculating similarity scores for all 3.25 million pairs of 2,550 human miRNAs, we found that this pattern frequently holds, while we also observed exceptions. Respective results were obtained for both, predicted target genes as well as experimentally validated targets. We note that miRNAs target gene set similarity follows a bimodal distribution, pointing at a set of 282 miRNAs that seems to target genes with very high specificity. Further, we discuss miRNAs with different (seed) sequences that nonetheless regulate similar gene sets or pathways. Most intriguingly, we found miRNA pairs that regulate different gene sets but similar pathways such as miR-6886-5p and miR-3529-5p. These are jointly targeting different parts of the MAPK signaling cascade. The main goal of this study is to provide a general overview on the results, to highlight a selection of relevant results on miRNAs, miRNA seeds, target genes and target pathways and to raise awareness for artifacts in respective comparisons. The full set of information that allows to infer detailed results on each miRNA has been included in miRPathDB, the miRNA target pathway database (https://mpd.bioinf.uni-sb.de).
DOI of the first publication: 10.18632/oncotarget.22363
URL of the first publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739805/
Link to this record: hdl:20.500.11880/28670
http://dx.doi.org/10.22028/D291-30211
ISSN: 1949-2553
Date of registration: 10-Feb-2020
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Hans-Peter Lenhof
Collections:UniBib – Die Universitätsbibliographie

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