Please use this identifier to cite or link to this item: doi:10.22028/D291-30196
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Title: RegulatorTrail: a web service for the identification of key transcriptional regulators
Author(s): Kehl, Tim
Schneider, Lara
Schmidt, Florian
Stöckel, Daniel
Gerstner, Nico
Backes, Christina
Meese, Eckart
Keller, Andreas
Schulz, Marcel H.
Lenhof, Hans-Peter
Language: English
Title: Nucleic acids research
Volume: 45
Issue: W1
Startpage: W146
Endpage: W153
Publisher/Platform: Oxford University Press
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Transcriptional regulators such as transcription factors and chromatin modifiers play a central role in most biological processes. Alterations in their activities have been observed in many diseases, e.g. cancer. Hence, it is of utmost importance to evaluate and assess the effects of transcriptional regulators on natural and pathogenic processes. Here, we present RegulatorTrail, a web service that provides rich functionality for the identification and prioritization of key transcriptional regulators that have a strong impact on, e.g. pathological processes. RegulatorTrail offers eight methods that use regulator binding information in combination with transcriptomic or epigenomic data to infer the most influential regulators. Our web service not only provides an intuitive web interface, but also a well-documented RESTful API that allows for a straightforward integration into third-party workflows. The presented case studies highlight the capabilities of our web service and demonstrate its potential for the identification of influential regulators: we successfully identified regulators that might explain the increased malignancy in metastatic melanoma compared to primary tumors, as well as important regulators in macrophages. RegulatorTrail is freely accessible at: https://regulatortrail.bioinf.uni-sb.de/.
DOI of the first publication: 10.1093/nar/gkx350
URL of the first publication: https://academic.oup.com/nar/article/45/W1/W146/3787856/
Link to this record: hdl:20.500.11880/28661
http://dx.doi.org/10.22028/D291-30196
ISSN: 1362-4962
0305-1048
1362-4954
Date of registration: 3-Feb-2020
Faculty: MI - Fakultät für Mathematik und Informatik
Department: MI - Informatik
Professorship: MI - Prof. Dr. Hans-Peter Lenhof
Collections:UniBib – Die Universitätsbibliographie

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