Please use this identifier to cite or link to this item: doi:10.22028/D291-29511
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Title: 4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues
Author(s): Zheng, Yijun
Liong Han, Mitchell Kim
Jiang, Qiyang
Li, Bin
Feng, Jun
del Campo Bécares, Aránzazu
Language: English
Title: Materials horizons
Volume: 7
Issue: 1
Startpage: 111
Endpage: 116
Publisher/Platform: RSC
Year of Publication: 2020
Publikation type: Journal Article
Abstract: Cooperative action of biochemical and biomechanical signals regulates the interactions between cells and the supporting matrix in natural tissues. Herein, we describe a hydrogel for 4D cell culture which allows user-defined stiffening of the cellular environment and presentation of bioadhesive cues in an orthogonal manner using light of different wavelengths. Stiffening of the gel is initiated by VIS light, while activation of the biochemical function is triggered by UV light. We demonstrate the versatility of this system by triggering, directing and/or hindering cell migration from spheroids based on photoactivated stiffening or integrin-binding to the hydrogels. This material allows in situ and independent manipulation of the physicochemical cues in the cellular microenvironment in vitro, and could eventually be extended to in vivo.
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Link to this record: hdl:20.500.11880/28621
ISSN: 2051-6355
Date of registration: 21-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:Die Universitätsbibliographie

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