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Titel: Selenides and Diselenides: A Review of Their Anticancer and Chemopreventive Activity
VerfasserIn: Álvarez-Pérez, Mónica
Ali, Wesam
Marć, Małgorzata Anna
Handzlik, Jadwiga
Domínguez-Álvarez, Enrique
Sprache: Englisch
Titel: Molecules
Bandnummer: 23
Heft: 3
Verlag/Plattform: MDPI
Erscheinungsjahr: 2018
Freie Schlagwörter: selenium
selenocompounds
DDC-Sachgruppe: 540 Chemie
Dokumenttyp: Journalartikel / Zeitschriftenartikel
Abstract: Selenium and selenocompounds have attracted the attention and the efforts of scientists worldwide due to their promising potential applications in cancer prevention and/or treatment. Different organic selenocompounds, with diverse functional groups that contain selenium, have been reported to exhibit anticancer and/or chemopreventive activity. Among them, selenocyanates, selenoureas, selenoesters, selenium-containing heterocycles, selenium nanoparticles, selenides and diselenides have been considered in the search for efficiency in prevention and treatment of cancer and other related diseases. In this review, we focus our attention on the potential applications of selenides and diselenides in cancer prevention and treatment that have been reported so far. The around 80 selenides and diselenides selected herein as representative compounds include promising antioxidant, prooxidant, redox-modulating, chemopreventive, anticancer, cytotoxic and radioprotective compounds, among other activities. The aim of this work is to highlight the possibilities that these novel organic selenocompounds can offer in an effort to contribute to inspire medicinal chemists in their search of new promising derivatives.
DOI der Erstveröffentlichung: 10.3390/molecules23030628
Link zu diesem Datensatz: urn:nbn:de:bsz:291--ds-275008
hdl:20.500.11880/28607
http://dx.doi.org/10.22028/D291-27500
ISSN: 1420-3049
Datum des Eintrags: 18-Jan-2020
Fakultät: NT - Naturwissenschaftlich- Technische Fakultät
Fachrichtung: NT - Pharmazie
Professur: NT - Prof. Dr. Claus Jacob
Sammlung:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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