Please use this identifier to cite or link to this item: doi:10.22028/D291-27493
Title: Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions
Author(s): Jardim, Guilherme A. M.
Lima, Daisy J. B.
Valença, Wagner O.
Lima, Daisy J. B.
Cavalcanti, Bruno C.
Pessoa, Claudia
Rafique, Jamal
Braga, Antonio L.
Jacob, Claus
da Silva Júnior, Eufrânio N.
da Cruz, Eduardo H. G.
Language: English
Title: Molecules
Volume: 23
Issue: 1
Publisher/Platform: MDPI
Year of Publication: 2018
DDC notations: 540 Chemistry
Publikation type: Journal Article
Abstract: In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC50 values below 1 µM. The cytotoxic potential of the naphthoquinoidal derivatives was also evaluated in non-tumor cells, exemplified by L929 cells. Overall, these compounds represent promising new lead derivatives and stand for a new class of chalcogenium-containing derivatives with potential antitumor activity.
DOI of the first publication: 10.3390/molecules23010083
Link to this record: urn:nbn:de:bsz:291--ds-274936
ISSN: 1420-3049
Date of registration: 17-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Claus Jacob
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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