Please use this identifier to cite or link to this item: doi:10.22028/D291-27481
Title: Nanosizing Cynomorium: Thumbs up for Potential Antifungal Applications
Author(s): Griffin, Sharoon
Alkhayer, Reem
Mirzoyan, Seda
Turabyan, Astghik
Zucca, Paolo
Sarfraz, Muhammad
Nasim, Muhammad Jawad
Trchounian, Armen
Rescigno, Antonio
Keck, Cornelia M.
Jacob, Claus
Language: English
Title: Inventions
Volume: 2
Issue: 3
Publisher/Platform: MDPI
Year of Publication: 2017
DDC notations: 600 Technology
Publikation type: Journal Article
Abstract: Cynomorium coccineum L., the desert thumb, is a rather exotic, parasitic plant unable to engage in photosynthesis, yet rich in a variety of unique compounds with a wide spectrum of biological applications. Whilst extraction, separation and isolation of such compounds is time consuming, the particular properties of the plant, such as dryness, hardness and lack of chlorophyll, render it a prime target for possible nanosizing. The entire plant, the external layer (coat) as well as its peel, are readily milled and high pressure homogenized to yield small, mostly uniform spherical particles with diameters in the range of 300 to 600 nm. The best quality of particles is obtained for the processed entire plant. Based on initial screens for biological activity, it seems that these particles are particularly active against the pathogenic fungus Candida albicans, whilst no activity could be observed against the model nematode Steinernema feltiae. This activity is particularly pronounced in the case of the external layer, whilst the peeled part does not seem to inhibit growth of C. albicans. Thanks to the ease of sample preparation, the good quality of the nanosuspension obtained, and the interesting activity of this natural product, nanosized coats of Cynomorium may well provide a lead for future development and applications as “green” materials in the field of medicine, but also environmentally, for instance in agriculture.
DOI of the first publication: 10.3390/inventions2030024
Link to this record: urn:nbn:de:bsz:291--ds-274817
ISSN: 2411-5134
Date of registration: 16-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Claus Jacob
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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