Please use this identifier to cite or link to this item: doi:10.22028/D291-27462
Title: The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s Disease
Author(s): Grimm, Marcus O. W.
Mett, Janine
Hartmann, Tobias
Language: English
Title: International Journal of Molecular Sciences
Volume: 17
Issue: 11
Publisher/Platform: MDPI
Year of Publication: 2016
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Alzheimer’s disease (AD) is the most common cause of dementia in the elderly population, currently affecting 46 million people worldwide. Histopathologically, the disease is characterized by the occurrence of extracellular amyloid plaques composed of aggregated amyloid-β (Aβ) peptides and intracellular neurofibrillary tangles containing the microtubule-associated protein tau. Aβ peptides are derived from the sequential processing of the amyloid precursor protein (APP) by enzymes called secretases, which are strongly influenced by the lipid environment. Several vitamins have been reported to be reduced in the plasma/serum of AD-affected individuals indicating they have an impact on AD pathogenesis. In this review we focus on vitamin E and the other lipophilic vitamins A, D, and K, and summarize the current knowledge about their status in AD patients, their impact on cognitive functions and AD risk, as well as their influence on the molecular mechanisms of AD. The vitamins might affect the generation and clearance of Aβ both by direct effects and indirectly by altering the cellular lipid homeostasis. Additionally, vitamins A, D, E, and K are reported to influence further mechanisms discussed to be involved in AD pathogenesis, e.g., Aβ-aggregation, Aβ-induced neurotoxicity, oxidative stress, and inflammatory processes, as summarized in this article.
DOI of the first publication: 10.3390/ijms17111785
Link to this record: urn:nbn:de:bsz:291--ds-274622
ISSN: 1422-0067
Date of registration: 10-Jan-2020
Faculty: M - Medizinische Fakultät
Department: M - Neurologie und Psychiatrie
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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