Please use this identifier to cite or link to this item: doi:10.22028/D291-27458
Title: Homogeneous Biosensing Based on Magnetic Particle Labels
Author(s): Schrittwieser, Stefan
Pelaz, Beatriz
Parak, Wolfgang J.
Lentijo-Mozo, Sergio
Soulantica, Katerina
Dieckhoff, Jan
Ludwig, Frank
Guenther, Annegret
Tschöpe, Andreas
Schotter, Joerg
Language: English
Title: Sensors
Volume: 16
Issue: 6
Publisher/Platform: MDPI
Year of Publication: 2016
DDC notations: 530 Physics
Publikation type: Journal Article
Abstract: The growing availability of biomarker panels for molecular diagnostics is leading to an increasing need for fast and sensitive biosensing technologies that are applicable to point-of-care testing. In that regard, homogeneous measurement principles are especially relevant as they usually do not require extensive sample preparation procedures, thus reducing the total analysis time and maximizing ease-of-use. In this review, we focus on homogeneous biosensors for the in vitro detection of biomarkers. Within this broad range of biosensors, we concentrate on methods that apply magnetic particle labels. The advantage of such methods lies in the added possibility to manipulate the particle labels by applied magnetic fields, which can be exploited, for example, to decrease incubation times or to enhance the signal-to-noise-ratio of the measurement signal by applying frequency-selective detection. In our review, we discriminate the corresponding methods based on the nature of the acquired measurement signal, which can either be based on magnetic or optical detection. The underlying measurement principles of the different techniques are discussed, and biosensing examples for all techniques are reported, thereby demonstrating the broad applicability of homogeneous <i>in vitro</i> biosensing based on magnetic particle label actuation.
DOI of the first publication: 10.3390/s16060828
Link to this record: urn:nbn:de:bsz:291--ds-274581
ISSN: 1424-8220
Date of registration: 7-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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