Please use this identifier to cite or link to this item: doi:10.22028/D291-27455
Title: miRTargetLink—miRNAs, Genes and Interaction Networks
Author(s): Hamberg, Maarten
Backes, Christina
Fehlmann, Tobias
Hart, Martin
Meder, Benjamin
Meese, Eckart
Keller, Andreas
Language: English
Title: International Journal of Molecular Sciences
Volume: 17
Issue: 4
Publisher/Platform: MDPI
Year of Publication: 2016
DDC notations: 500 Science
610 Medicine and health
Publikation type: Journal Article
Abstract: Information on miRNA targeting genes is growing rapidly. For high-throughput experiments, but also for targeted analyses of few genes or miRNAs, easy analysis with concise representation of results facilitates the work of life scientists. We developed miRTargetLink, a tool for automating respective analysis procedures that are frequently applied. Input of the web-based solution is either a single gene or single miRNA, but also sets of genes or miRNAs, can be entered. Validated and predicted targets are extracted from databases and an interaction network is presented. Users can select whether predicted targets, experimentally validated targets with strong or weak evidence, or combinations of those are considered. Central genes or miRNAs are highlighted and users can navigate through the network interactively. To discover the most relevant biochemical processes influenced by the target network, gene set analysis and miRNA set analysis are integrated. As a showcase for miRTargetLink, we analyze targets of five cardiac miRNAs. miRTargetLink is freely available without restrictions at www.ccb.uni-saarland.de/mirtargetlink.
DOI of the first publication: 10.3390/ijms17040564
Link to this record: urn:nbn:de:bsz:291--ds-274557
hdl:20.500.11880/28549
http://dx.doi.org/10.22028/D291-27455
ISSN: 1422-0067
Date of registration: 6-Jan-2020
Faculty: M - Medizinische Fakultät
Department: M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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