Please use this identifier to cite or link to this item: doi:10.22028/D291-27443
Title: Aspects of a Distinct Cytotoxicity of Selenium Salts and Organic Selenides in Living Cells with Possible Implications for Drug Design
Author(s): Estevam, Ethiene Castellucci
Witek, Karolina
Faulstich, Lisa
Nasim, Jawad
Latacz, Gniewomir
Domínguez-Álvarez, Enrique
Kieć-Kononowicz, Katarzyna
Demasi, Marilene
Handzlik, Jadwiga
Jacob, Claus
Language: English
Title: Molecules
Volume: 20
Issue: 8
Startpage: 13894
Endpage: 13912
Publisher/Platform: MDPI
Year of Publication: 2015
DDC notations: 540 Chemistry
Publikation type: Journal Article
Abstract: Selenium is traditionally considered as an antioxidant element and selenium compounds are often discussed in the context of chemoprevention and therapy. Recent studies, however, have revealed a rather more colorful and diverse biological action of selenium-based compounds, including the modulation of the intracellular redox homeostasis and an often selective interference with regulatory cellular pathways. Our basic activity and mode of action studies with simple selenium and tellurium salts in different strains of Staphylococcus aureus (MRSA) and Saccharomyces cerevisiae indicate that such compounds are sometimes not particularly toxic on their own, yet enhance the antibacterial potential of known antibiotics, possibly via the bioreductive formation of insoluble elemental deposits. Whilst the selenium and tellurium compounds tested do not necessarily act via the generation of Reactive Oxygen Species (ROS), they seem to interfere with various cellular pathways, including a possible inhibition of the proteasome and hindrance of DNA repair. Here, organic selenides are considerably more active compared to simple salts. The interference of selenium (and tellurium) compounds with multiple targets could provide new avenues for the development of effective antibiotic and anticancer agents which may go well beyond the traditional notion of selenium as a simple antioxidant.
DOI of the first publication: 10.3390/molecules200813894
Link to this record: urn:nbn:de:bsz:291--ds-274435
hdl:20.500.11880/28537
http://dx.doi.org/10.22028/D291-27443
ISSN: 1420-3049
Date of registration: 6-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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