Please use this identifier to cite or link to this item: doi:10.22028/D291-27431
Title: Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer
Author(s): Yin, Lina
Hu, Qingzhong
Hartmann, Rolf W.
Language: English
Title: International Journal of Molecular Sciences
Volume: 14
Issue: 7
Startpage: 13958
Endpage: 13978
Publisher/Platform: MDPI
Year of Publication: 2013
DDC notations: 540 Chemistry
610 Medicine and health
Publikation type: Journal Article
Abstract: Since 2010, six drugs have been approved for the treatment of castration-resistant prostate cancer, i.e., CYP17 inhibitor Abiraterone, androgen receptor antagonist Enzalutamide, cytotoxic agent Cabazitaxel, vaccine Sipuleucel-T, antibody Denosumab against receptor activator of nuclear factor kappa B ligand and radiopharmaceutical Alpharadin. All these drugs demonstrate improvement on overall survival, expect for Denosumab, which increases the bone mineral density of patients under androgen deprivation therapy and prolongs bone-metastasis-free survival. Besides further CYP17 inhibitors (Orteronel, Galeterone, VT-464 and CFG920), androgen receptor antagonists (ARN-509, ODM-201, AZD-3514 and EZN-4176) and vaccine Prostvac, more drug candidates with various mechanisms or new indications of launched drugs are currently under evaluation in different stages of clinical trials, including various kinase inhibitors and platinum complexes. Some novel strategies have also been proposed aimed at further potentiation of antitumor effects or reduction of side effects and complications related to treatments. Under these flourishing circumstances, more investigations should be performed on the optimal combination or the sequence of treatments needed to delay or reverse possible resistance and thus maximize the clinical benefits for the patients.
DOI of the first publication: 10.3390/ijms140713958
Link to this record: urn:nbn:de:bsz:291--ds-274317
ISSN: 1422-0067
Date of registration: 3-Jan-2020
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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