Please use this identifier to cite or link to this item: doi:10.22028/D291-29978
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Title: Assessment of the “cross-bridge”-induced interaction of red blood cells by optical trapping combined with microfluidics
Author(s): Lee, Kisung
Wagner, Christian
Priezzhev, Alexander V.
Language: English
Title: Journal of biomedical optics
Volume: 22
Issue: 9
Startpage: 1
Endpage: 6
Publisher/Platform: SPIE
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Red blood cell (RBC) aggregation is an intrinsic property of the blood that has a direct effect on the blood viscosity and circulation. Nevertheless, the mechanism behind the RBC aggregation has not been confirmed and is still under investigation with two major hypotheses, known as “depletion layer” and “cross-bridging.” We aim to ultimately understand the mechanism of the RBC aggregation and clarify both models. To measure the cell interaction in vitro in different suspensions (including plasma, isotonic solution of fibrinogen, isotonic solution of fibrinogen with albumin, and phosphate buffer saline) while moving the aggregate from one solution to another, an approach combining optical trapping and microfluidics has been applied. The study reveals evidence that RBC aggregation in plasma is at least partly due to the cross-bridging mechanism. The cell interaction strength measured in the final solution was found to be significantly changed depending on the initial solution where the aggregate was formed.
DOI of the first publication: 10.1117/1.JBO.22.9.091516
URL of the first publication:
Link to this record: hdl:20.500.11880/28365
ISSN: 1560-2281
Date of registration: 22-Nov-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Christian Wagner
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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