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|Title:||Numerical-experimental observation of shape bistability of red blood cells flowing in a microchannel|
|Year of Publication:||2018|
|Publikation type:||Journal Article|
|Abstract:||Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. Predicting the realized shapes is a complex field as they are determined by the intricate interplay between the flow conditions and the membrane mechanics. In this work we construct the shape phase diagram of a single red blood cell with a physiological viscosity ratio flowing in a microchannel. We use both experimental in vitro measurements as well as 3D numerical simulations to complement the respective other one. Numerically, we have easy control over the initial starting configuration and natural access to the full 3D shape. With this information we obtain the phase diagram as a function of initial position, starting shape and cell velocity. Experimentally, we measure the occurrence frequency of the different shapes as a function of the cell velocity to construct the experimental diagram which is in good agreement with the numerical observations. Two different major shapes are found, namely croissants and slippers. Notably, both shapes show coexistence at low (<1 mm s−1) and high velocities (>3 mm s−1) while in-between only croissants are stable. This pronounced bistability indicates that RBC shapes are not only determined by system parameters such as flow velocity or channel size, but also strongly depend on the initial conditions.|
|DOI of the first publication:||10.1039/C7SM02272G|
|URL of the first publication:||https://pubs.rsc.org/en/content/articlelanding/2018/sm/c7sm02272g#!divAbstract|
|Link to this record:||hdl:20.500.11880/28362|
|Date of registration:||22-Nov-2019|
|Faculty:||NT - Naturwissenschaftlich- Technische Fakultät|
|Department:||NT - Physik|
|Professorship:||NT - Prof. Dr. Christian Wagner|
|Collections:||SciDok - Der Wissenschaftsserver der Universität des Saarlandes|
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